|Place of Origin:||China|
|Minimum Order Quantity:||10 Grams|
|Price:||1.5 usd dollars per gram|
|Packaging Details:||Discreet and safe foil bag|
|Delivery Time:||Within 12hours after payment|
|Payment Terms:||West Union, T/T, Money Gram.,Bitcorn and bank transfer, D/P|
|Supply Ability:||10000 Kg|
|Storage:||Store In Original Container In A Cool Dark Place.||Functions:||Anti-Tumor Drug|
Azd2171 Cediranib CAS 288383-20-0 for Ovarian Cancer ( EOC) Anti-Tumor Drug
Cediranib;4-(4-Fluoro-2-methylindol-5-yloxy)-6-methoxy-7-[3-(pyrrolidin-1-yl)propoxy]quinazoline;Cadiranib (AZD2171);Cediranib(AZD2171);AZD2171;Recentin;Cadiranib;Cediranib R
Pharmaceutical Raw Materials,Active Pharmaceutical Ingredients,Bulk Drugs,Fine Chemicals.
Store in original container in a cool dark place.
Description:Cediranib is a highly potent inhibitor of VEGFR with IC50 value of <1 nM.
Cediranib (tentative trade name Recentin), also known as AZD2171, is a potent inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinases. It is a inhibitor with IC50 of <1 nM, also inhibits Flt1/4 with IC50of 5 nM/≤3 nM, similar activity against c-Kit and PDGFRβ, 36-, 110-fold and >1000-fold selective more for VEGFR than PDGFR-α, CSF-1R and Flt3, Phase 2/3.
It is being developed by AstraZenecaas a possible anticancer chemotherapeutic agent for oral administration.
|Specific rotation||+39.5 to +41.5°|
|State of solution(transmittance)||Clear 98.0% min.|
|Ammonium [NH4]||0.02% max.|
|Heavy metals [Pb]||10ppm max|
|Other amino acids||Chromatographically not detectable|
|Loss on drying||0.20% max.|
|Residue on ignition[sulfated]||0.10% max.|
Cediranib inhibition of bFGF and EGF when an IC50 of 0.5 and 0.11 μM. In the MG63 cell lines, Cediranib inhibiting PDGF-AA, IC50 of 0.04 μM. Cediranib Flt-1 associated kinase inhibition, IC50 of 5 nM,
Cediranib inhibition of VEGF-C and VEGF-D receptor Flt-4, IC50 of less than 3 nM. In addition, cediranib inhibition of c-Kit and PDGFR-β tyrosine kinase, IC50 were 2 and 5 nM. In vitro, micromolar concentrations cediranib can directly inhibit the proliferation of tumor cells.
Sub nanomolar Cediranib blocking tubules produced, and inhibits VEGF-induced angiogenesis in vivo.
1kg/Aluminum foil bag
1kg/ Aluminium Tin
25kg/ Aluminum Drum
Usually within 2 working days after confirming the payment.
DHL; TNT; UPS or EMS
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Payment: Western Union, MoneyGram We will supply the receiver's information or the bank account information for payment use.
Shipping items: Shipping items will be delivered by international express like EMS, TNT, UPS, FedEx or DHL after receiving received.
Every item will be shipped out in 1-2working days after the payment is done. The product usually arrives in 1-4 days based on the different destination, and online track is provided. Please kindly supply the shipping address, contact and tel number for successful shipment.
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